Photostability Chambers
Models 6540-1, 6545-1, 6540-2, 6545-2, 6540-3 & 6545-3

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The 6540 Series Photostability chambers were specifically designed to perform near UV and visual light testing with fluorescent lamps per ICH Q1B Guidelines, Option 2.  This second generation benchtop unit controls light and temperature conditions through an easy-to-use color touch-screen interface.  Lights automatically shut off after a specified exposure level or time duration.  Uniform light distribution and high intensity levels allow quick response for forced degradation testing and confirmatory studies.  Precise humidity control (Models 6545-1, 6545-2 & 6545-3) is achieved through ultrasonic injection and mechanical refrigeration methods.

As with all CARON manufactured products, chambers sold in North America are fully covered by our 12-month standard warranty agreement.  Installation and validation services are also available.  Please contact your local international distributor for warranty and validation services in other areas.
 

Standard Features

• Independent control of near UV and cool white VIS lamps are provided to eliminate overexposure for confirmatory tests and provide flexibility for forced degradation studies.
• In "Automatic" mode, lights turn off at the end of a programmed exposure or timed test.
• "Manual" mode allows a flexible test time duration and makes validating the chambers easy.
• Dimmable lamps (230V models) allow testing at specific light intensity levels.
• Programmable alarms notify the user when aging lamps should be replaced.
• Specular aluminum reflective surfaces provide uniform UVA & VIS light reflection and maintain proper SPD (spectral power distribution).
• Stainless steel interior construction provides a smooth, non-porous surface for easy maintenance.
• Two light detectors (one VIS and one UVA) with an integral radiometer are standard and provide precise and accurate light intensity measurements.  Light detectors are both cosine corrected and calibrated to NIST traceable standards.
• Precise temperature control is provided through use of a PID controller.
• Humidity controlled units (Models 6545-1, 6545-2 & 6545-3) isolate the effects of hydration during photostability testing.
• Shelves slide out for quick and easy loading and unloading of samples.
• Strategic lamp spacing provides enhanced light uniformity.  Overhead lighting results in a large illumination area for maximized direct lighting.
• Door safety switch turns lights off when the door is opened.  The lockable door prevents additional disturbance of in-process tests.
•  Two access ports (one per shelf) are standard.
  
  

Main Screen Display

•  Performance is managed through an eye level, icon-based, color, touch-screen interface for user convenience.
• The easy-to-use controls are written in multiple languages (English, Spanish, German and French).
• Temperature, humidity, and light meters can be quickly programmed.  Test results are easy to interpret.
• Pull-out, removable light banks allow for quick bulb replacement without the use of tools.
• Modular refrigeration system and front access, slide-out electrical chassis are easy to service.
• Units contain off-the-shelf components that are readily available.

  
  Product Specifications
  
  

  Model	6540-1	6545-1	6540-2	6545-2	6540-3	6545-3
  Lamp Type, UVA	Fluorescent, near UV (black lamp)
  Lamp Type, VIS	Fluorescent, cool white (ISO 10977 compliant)
  Light Detectors	UVA and Visual, calibrated
  UVA Light Intensity, Typical	20 W/m2		2-30 W/m2
  VIS Light Intensity, Typical	20 klux		2-35 klux
  Lamps Dimming	n/a		3-100%
  Typical Time Required to Reach ICH Recommendation of 200 W-hr/m2	10 hrs.		7 hrs.
  Typical Time Required to Reach ICH Recommendation of 1.2 million lux-hr	60 hrs.		35 hrs.
  Light Uniformity	UVA:  ±10% VIS:  ±15%		UVA:  ±10% VIS:  ±15%
  Temperature Range	10°C to 35°C (lights on)
  Temperature Control	± 0.2°C (lights on)
  Temperature Uniformity	± 2.5°C (lights on)
  Humidity Range	n/a	40-70% RH	n/a	40-70% RH	n/a	40-70% RH
  Humidity Control	n/a	± 3%	n/a	± 3%	n/a	± 3%
  # of Shelves, Size	Two (2) sliding, 26.0" W x 23.1" D x 8.0" H (660mm W x 587mm D x 203mm H) each
  Usable Shelf Area, Each	19.0" x 23.0" (483mm x 584mm)
  Usable Shelf Area, Total	6.1 sq. ft. (0.56 m2) per shelf; 76% of total shelf
  Maximum Weight per Shelf	22 lbs. (10 kg)
  Interior Surfaces	Reflective Specular Aluminum
  Interior Construction	Stainless Steel
  Internal Volume	10.5 sq. ft. (296L), includes lamp space
  Exterior Dimensions	37.6" W x 30.2" D x 46.0" H w/leveling feet (955mm W x 767mm D x 1168mm H)
  Interior Dimensions	26.9" W x 24.0" D x 28.0" H (683mm W x 610mm D x 711mm H)
  # of Access Ports	Two (2), 1.75" W x 2.0" H each (44mm W x 51mm H)
  Shipping Weight	700 lbs. (900 lbs. with export crate)
  Electrical Service	115V, 60 Hz, 15A		208/230V, 60 Hz, 15A		230V, 50 Hz, 10A

  Specifications are subject to change without notice.  Specifications were established with lights fully on at 20°C, with 20°C and 50% RH ambient conditions.  RH levels limited by a 6°C minimum dewpoint.  50 Hz units are CE Marked and contain readily available components.
  
  To view our "Using Photostability Test Chambers to Meet the Requirements of Drug Testing in Accordance with ICH Q1B" white paper, click here.

Catalog No.	Name	Unit of Issue	Models
CART102	Laboratory Equipment Cart	Each	6010, 6011, 6012, 6540, 6545
	Heavy duty, 48"x30"x24"H, laboratory euqipment cart. Reinforced, removable, heavy-duty, solid 12 ga. aluminum top. Aluminum undershelf provides convenient storage space. 5" stem-type casters with brakes. Accommodates equipment up to 800 lbs.
CRSY102	Condensate Recirculator	Each	6010, 6030, 6034, 6035, 6105, 6545
	Condensate recirculating system most commonly used with the chamber when necessary in-house water supply or floor drain is unavailable, or as an attempt to conserve water usage. Collects, filters, and reuses water as the unit calls for humidity.
CRSYKIT	Condensate Circulator Kit	Each	6010, 6030, 6034, 6035, 6105, 6545
	Tubing and fitting kit to connect CRSY102 to two chambers.
EXTD005	Extended Temp Range	Each	6540, 6545
	Extended temperature down to +5C (with lights on)
EXTD045	Extended Temp/RH Range	Each	6545
	Extended temperature up to +45C. Extended humidity range to 80%. (light bank removed)
FLTR101	Filter	Each	6010, 6030, 6034, 6035, 6105, 6545
	Filter replacement kit for CRSY102. Includes DI cartridge, carbon filter, and silver stick.
LGHT503	Replacement Lamps	Each	6540, 6545
	Black light bank replacement kit for 115V models. Includes (6) 20 Watt lamps.
LGHT504	Replacement Lamps	Each	6540, 6545
	White light bank replacement kit for 115V models. Includes (10) 35 Watt lamps.
LGHT505	Replacement Lamps	Each	6540, 6545
	Black light bank replacement kit for 230V models. Includes (6) 18 Watt lamps.
LGHT506	Replacement Lamps	Each	6540, 6545
	White light bank replacement kit for 230V models. Includes (14) 18 Watt lamps.
LGHT601	UV Germicidal Lamp	Each	6010, 6030, 6034, 6035, 6105, 6545
	Ultraviolet germicidal lamp deactivates microorganisms, for CRYS102
RCDR103	Recorder	Each	6010, 6030, 6034, 6035, 6545
	Temperature/humidity recorder. Honeywell, 2 pen, 7 day, 10" circular chart.
RCDR111	Recorder	Each	6010, 6030, 6034, 6035, 6545
	Built-in temperature recorder. Cobex, 2 pen, 24 hour or 7 day, 6" circular chart.
RCDR204	Recorder	Each	6545
	Circular, 12", Honeywell Truline Chart Recorder. Records and charts four variables.
TABL101	Stainless Steel Work Table	Each	6540, 6545, 6010, 6011, 6012
	Heavy-duty Laboratory Equipment Cart (48"x30"x35"H). Cabinet base has sliding doors, 1-1/4" turn down lip on four sides, 14 ga. stainless steel top, adjustable legs, and undershelf. Shipped fully assembled.
VLD-640	IQ/OQ Protocol	Each	6540, 6545
	Protocol for installation and operation qualification (IQ/OQ), in professional binder.
VLD-641	Full Validation	Each	6540, 6545
	Full on-site IQ/OQ/PQ validation. Uses VLD-640 protocol (included).